Background

I graduated from Moscow State University and got my Ph.D in genetics there. In 1990 my family moved to the United States and I joined Dan’s lab at Washington University in St. Louis. During my tenure in the lab I participated in almost all major projects: Structure and sequence of the Drosophila melanogaster genome; genome structure and evolution in D. virilis; cosuppression of transposable elements and hybrid dysgenesis; C-value paradox; and the transposable element mariner. For the last several years, I’m involved with the study of evolution of drug resistance of dhfr in Plasmodium and bacteria.

Research Interests

Recent Publications

Rodrigues J.V, Bershtein Sh, Li A., Lozovsky E.R, Hartl D.L,and Shakhnovich E.I.

Biophysical Principles Predict Fitness Landscapes of Drug Resistance. PNAS 2016,

in press

Jiang PP, Corbett-Detig RB, Hartl DL, Lozovsky ER. Accessible mutational

trajectories for the evolution of pyrimethamine resistance in the malaria

parasite Plasmodium vivax. J Mol Evol. 2013 Sep;77(3):81-91.

Brown KM, Costanzo MS, Xu W, Roy S, Lozovsky ER, Hartl DL. Compensatory

mutations restore fitness during the evolution of dihydrofolate reductase. Mol

Biol Evol. 2010 Dec;27(12):2682-90.

Lozovsky ER, Chookajorn T, Brown KM, Imwong M, Shaw PJ, Kamchonwongpaisan S,

Neafsey DE, Weinreich DM, Hartl DL. Stepwise acquisition of pyrimethamine

resistance in the malaria parasite. Proc Natl Acad Sci U S A. 2009 Jul

21;106(29):12025-30.

Schaeffer SW, Bhutkar A, et al. Polytene chromosomal maps of 11 Drosophila

species: the order of genomic scaffolds inferred from genetic and physical maps.

Genetics. 2008 Jul;179(3):1601-55.

Drosophila 12 Genomes Consortium.

Evolution ofgenes and genomes on the Drosophila phylogeny. Nature. 2007 Nov

8;450(7167):203-18.

Volkman SK, Lozovsky E, Barry AE, Bedford T, Bethke L, Myrick A, Day KP, Hartl

DL, Wirth DF, Sawyer SA. Genomic heterogeneity in the density of noncoding

single-nucleotide and microsatellite polymorphisms in Plasmodium falciparum.

Gene. 2007 Jan 31;387(1-2):1-6.

Bethke LL, Zilversmit M, Nielsen K, Daily J, Volkman SK, Ndiaye D, Lozovsky

ER, Hartl DL, Wirth DF. Duplication, gene conversion, and genetic diversity in

the species-specific acyl-CoA synthetase gene family of Plasmodium falciparum.

Mol Biochem Parasitol. 2006 Nov;150(1):10-24.

Nielsen, K. M., J. Kasper, M. Choi, T. Bedford, K. Kristiansen, D. F. Wirth, S. K. Volkman, E. R. Lozovsky, and D. L. Hartl, 2003 Gene conversion as a source of nucleotide diversity in Plasmodium falciparum. Mol. Biol. Evol. 20: 726-734.

Blumenstiel, J. P., D. L. Hartl, and E. R. Lozovsky, 2002 Patterns of insertion and deletion in contrasting chromatin domains. Mol. Biol. Evol. 19(12): 2211-2225.

Lozovsky, E. R., D. Nurminsky, E. A. Wimmer and D. L. Hartl, 2002 Unexpected stability of mariner transgenes in Drosophila. Genetics 160: 527-535.

Lozovsky, E. R., 2001 Test Bank and Student Solutions Manual and Supplemental Problems Book, (Learning Supplements for Genetics: Analysis of genes and genomes by D. L. Hartl and E. W. Jones), Jones and Bartlett, Boston, Massachusetts.

Lozovskaya, E. R., 2000 Preparation of DNA from E. coli cells containing bacteriophage P1 clones. In Drosophila Protocols. Cold Spring Harbor Lab. Press.

Biessmann, H., M. Zurovcova, J. G. Yao, E. Lozovskaya, and M. F. Walter, 2000 A telomeric satellite in Drosophila virilis and its sibling species. Chromosoma. 109(6): 372-80.

Lohe, A. R., C. Timmons, I. Beerman, E. R. Lozovskaya, D. L. Hartl, 2000 Self-inflicted wounds, template-directed gap repair, and a recombination hotspot: Effects of the mariner transposase. Genetics 154: 647-656.

Lozovskaya, E. R., D. I. Nurminsky, D. A. Petrov and D. L. Hartl 1999 Genome size as a mutation-selection-drift process. Genes Genet. Syst. 74: 201-207.

Schienman, J. E., E. R. Lozovskaya, and L. D. Strausbaugh, 1998 Drosophila virilis has atypical kinds and arrangements of histone repeats. Chromosoma, 107: 529-539.

Vieira, J., C. P. Vieira, D. L. Hartl, and E. R. Lozovskaya. 1998 Factors contributing to the hybrid dysgenesis syndrome in Drosophila virilis. Genet. Res. 71: 109-117.

Hartl, D. L., A. R. Lohe, and E. R. Lozovskaya, 1997 Regulation of the transposable element mariner. Genetica 100: 177-184.

Hartl, D. L., A. R. Lohe, and E. R. Lozovskaya, 1997 Modern thoughts on an ancyent marinere: Function, evolution, regulation. Ann. Rev. Genet. 31: 337-358.

Vieira, J., C. P. Vieira, D. L. Hartl and E. R. Lozovskaya, 1997 A framework physical map of Drosophila virilis based on P1 clones: Applications in genome evolution. Chromosoma 106: 99-107.

Hartl, D. L., E. R. Lozovskaya, D. I. Nurminsky, and A. R. Lohe, 1997 What restricts the activity of mariner-like transposable elements? Trends Genet. 13: 197-201.

Lozovskaya, E. R., 1997 Essential Genetics Through Problem Solving. Jones and Bartlett, Boston, Massachusetts.

Petrov, D. A., E. R. Lozovskaya and D. L. Hartl, 1996 High intrinsic rate of DNA loss in Drosophila. Nature 384: 346-349.

Lozovskaya, E. R., D. I. Nurminsky, D. L. Hartl and D. T. Sullivan, 1996 Germline tranformation of Drosophila virilis mediated by the transposable element hobo. Genetics 142: 173-177.

Nurminsky, D. I., E. N. Moriyama, E. R. Lozovskaya, and D. L. Hartl, 1996 Molecular phylogeny and genome evolution in the Drosophila virilis species group: Duplications of the alcohol dehydrogenase gene. Mol. Biol. Evol. 13: 132-149.

Lozovskaya, E. R., D. L. Hartl and D. A. Petrov, 1995 Genomic regulation of transposable elements in Drosophila. Current Opinion in Genetics and Development 5: 768-773.

Segarra, C., E. R.Lozovskaya, G. Ribo, M. Aguade, and D. L. Hartl, 1995 P1 clones from Drosophila melanogaster as markers to study chromosomal evolution of Muller's A element in two species of the obscura group of Drosophila. Chromosoma 104: 129-136.

Petrov, D. A., J. L. Schutzman, D. L. Hartl and E. R. Lozovskaya, 1995 Diverse transposable elements are mobilized in hybrid dysgenesis in Drosophila virilis. Proc. Natl. Acad. Sci. USA 92: 8050-8054

Hartl, D. L., and E. R. Lozovskaya, 1995 The Drosophila genome map: a practical guide. R.G. Landes, Austin, Texas.

Hartl, D., D. Nurminsky, R. Jones, and E. Lozovskaya, 1994 Genome structure and evolution in Drosophila: Applications of the framework P1 map. Proc. Natl. Acad. Sci. USA 91: 6824-6829.

Petrov, D., E. Lozovskaya, J. Schutzman, and D. Hartl, 1994 Hybrid dysgenesis in Drosophila virilis mobilizes many transposable elements, one of which is shared with Drosophila melanogaster. Abstracts of 35th Annual Drosophila Research Conference, p. 3.

Lozovskaya, E. R., D. A. Petrov, and D. L. Hartl, 1993 A combined molecular and cytogenetic approach to genome evolution in Drosophila using large-fragment DNA cloning. Chromosoma 102: 253-266.

Hartl, D., and E. Lozovskaya, 1992 The Drosophila genome project: current status of the physical map. Biochem. Physiol. 103B: 1-8.

Hartl, D., E. Lozovskaya, and J. Lawrence, 1992 Nonautonomous transposable elements in prokaryotes and eukaryotes. Genetica 86: 47-53.

Hartl, D., J. Ajioka, H. Cai, A. Lohe, E. Lozovskaya, D. Smoller, and I. Duncan, 1992 Towards a Drosophila genome map. Trends in Genet. 8: 70-75.

Lozovskaya, E., V. Scheinker, and M. Evgen'ev, 1991 New type of hybrid dysgenesis discovered in D. virilis. Dros. Inf. Serv. 70: 134-136.

Lozovskaya, E., and M. Evgen'ev, 1991 New mutants obtained by means of hybrid dysgenesis in D. virilis. Dros. Inf. Serv. 70: 277-279.

Scheinker, V., E. Lozovskaya, J. G. Bishop, V. G. Corces, and M. B. Evgen'ev, 1990 A long terminal repeat-containing retrotransposon is mobilized during hybrid dysgenesis in D. virilis. Proc. Natl. Acad. Sci. USA 87: 9615-9619.

Lozovskaya, E., V. Scheinker, and M. Evgen'ev, 1990 A hybrid dysgenesis syndrome in D. virilis. Genetics 126: 619-623.

Lozovskaya, E., and M. Evgen'ev, 1987 New system of hybrid dysgenesis. Proc. Acad. Sci. USSR 296: 727-731.

Lozovskaya, E., and M. Evgen'ev, 1984 Heat shock and regulation of gene expression. In: Review of Sciences. Molecular Biology, Moscow.

Neyfakh, A., and E. Lozovskaya, 1984 Genes and Development. Nauka, Moscow.

Evgen'ev, M., A. Levin, and E. Lozovskaya, 1979 The analysis of a temperature-sensitive (ts) mutation influencing the expression of heat-shock-inducible genes in Drosophila melanogaster. Molec. Gen. Genet. 176: 275-280.

Hobbies