@article {538531,
	title = {Genetic variation in IncI1-ColIb plasmids},
	journal = {J Mol EvolJ Mol EvolJ Mol Evol},
	volume = {39},
	number = {2},
	year = {1994},
	note = {Ayala, F JKrane, D EHartl, D LengGM40322/GM/NIGMS NIH HHS/Comparative StudyResearch Support, U.S. Gov{\textquoteright}t, P.H.S.1994/08/01J Mol Evol. 1994 Aug;39(2):129-33.},
	month = {Aug},
	pages = {129-33},
	abstract = {Nucleotide sequences of portions of three plasmid genes (cib, cir, and abi) present in IncI1-ColIb colicin plasmids obtained from strains of Salmonella typhimurium isolated in either 1974 (Barker strains) or between 1935 and 1941 (Murray strains) were examined along with sequences of the chromosomal gene for 6-phosphogluconate dehydrogenase (gnd). Our principal findings were: (1) The plasmid genes were virtually identical to those in IncI1-ColIb plasmids from E. coli, suggesting that Salmonella and E. coli share overlapping pools of these plasmids. (2) The plasmid genes were much less polymorphic than gnd or any other known chromosomal gene from Salmonella, further suggesting horizontal transfer with rapid transmission and turnover. (3) No characteristic differences were found in either the plasmid genes or the chromosomal gene between the 1974 isolates and the Murray strains, indicating that these plasmids have been stable for at least several decades. (4) There was an excess of amino-acid replacement polymorphisms, relative to synonymous polymorphisms, in the plasmid genes, which is consistent with the hypothesis of diversifying selection among colicin-producing plasmid families. (5) The abi (abortive infection) gene present in each of the plasmids contained two single-nucleotide insertions relative to the published sequence. These result in a putative abi protein of 114 amino acids instead of 89.},
	keywords = {Bacteriocin Plasmids/*genetics, Base Sequence, DNA, Complementary, Gene Expression Regulation, Bacterial, Genetic Variation, Molecular Sequence Data, Plasmids/*genetics, Polymerase Chain Reaction, Salmonella typhimurium/*genetics, Sequence Alignment},
	isbn = {0022-2844 (Print)0022-2844 (Linking)},
	author = {Ayala, F. J. and Krane, D. E. and Hartl, D. L.}
}
