@article {538561,
	title = {Optimization of gene expression by natural selection},
	journal = {Proc Natl Acad Sci U S A},
	volume = {106},
	number = {4},
	year = {2009},
	note = {<p>Bedford, TrevorHartl, Daniel LengGM065169/GM/NIGMS NIH HHS/GM084236/GM/NIGMS NIH HHS/Research Support, N.I.H., ExtramuralResearch Support, U.S. Gov{\textquoteright}t, Non-P.H.S.2009/01/14 09:00Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1133-8. doi: 10.1073/pnas.0812009106. Epub 2009 Jan 12.</p>},
	month = {Jan 27},
	pages = {1133-8},
	abstract = {<p>It is generally assumed that stabilizing selection promoting a phenotypic optimum acts to shape variation in quantitative traits across individuals and species. Although gene expression represents an intensively studied molecular phenotype, the extent to which stabilizing selection limits divergence in gene expression remains contentious. In this study, we present a theoretical framework for the study of stabilizing and directional selection using data from between-species divergence of continuous traits. This framework, based upon Brownian motion, is analytically tractable and can be used in maximum-likelihood or Bayesian parameter estimation. We apply this model to gene-expression levels in 7 species of Drosophila, and find that gene-expression divergence is substantially curtailed by stabilizing selection. However, we estimate the selective effect, s, of gene-expression change to be very small, approximately equal to Ns for a change of one standard deviation, where N is the effective population size. These findings highlight the power of natural selection to shape phenotype, even when the fitness effects of mutations are in the nearly neutral range.</p>},
	keywords = {*Gene Expression, *Selection, Genetic, Animals, Drosophila Proteins/genetics/metabolism, Drosophila/*genetics, Evolution, Molecular, Genetic Variation, Models, Genetic},
	isbn = {1091-6490 (Electronic)0027-8424 (Linking)},
	author = {Bedford, T. and Hartl, D. L.}
}
