@article {539966,
	title = {Meta-analysis reveals that genes regulated by the Y chromosome in Drosophila melanogaster are preferentially localized to repressive chromatin},
	journal = {Genome Biol Evol},
	volume = {5},
	number = {1},
	year = {2013},
	note = {<p>Sackton, Timothy BHartl, Daniel LengGM084236/GM/NIGMS NIH HHS/Meta-AnalysisResearch Support, N.I.H., ExtramuralEngland2013/01/15 06:00Genome Biol Evol. 2013;5(1):255-66. doi: 10.1093/gbe/evt005.</p>},
	pages = {255-66},
	abstract = {<p>The Drosophila Y chromosome is a degenerated, heterochromatic chromosome with few functional genes. Despite this, natural variation on the Y chromosome in D. melanogaster has substantial trans-acting effects on the regulation of X-linked and autosomal genes. It is not clear, however, whether these genes simply represent a random subset of the genome or whether specific functional properties are associated with susceptibility to regulation by Y-linked variation. Here, we present a meta-analysis of four previously published microarray studies of Y-linked regulatory variation (YRV) in D. melanogaster. We show that YRV genes are far from a random subset of the genome: They are more likely to be in repressive chromatin contexts, be expressed tissue specifically, and vary in expression within and between species than non-YRV genes. Furthermore, YRV genes are more likely to be associated with the nuclear lamina than non-YRV genes and are generally more likely to be close to each other in the nucleus (although not along chromosomes). Taken together, these results suggest that variation on the Y chromosome plays a role in modifying how the genome is distributed across chromatin compartments, either via changes in the distribution of DNA-binding proteins or via changes in the spatial arrangement of the genome in the nucleus.</p>},
	keywords = {*Genes, Insect, Animals, Chromosomes, Insect/*genetics/metabolism, DNA-Binding Proteins/metabolism, Drosophila melanogaster/*genetics/metabolism, Gene Expression Profiling, Gene Expression Regulation, Genetic Variation, Heterochromatin/*genetics/metabolism, Oligonucleotide Array Sequence Analysis, Regulatory Elements, Transcriptional, Transcription, Genetic, Y Chromosome/*genetics/metabolism},
	isbn = {1759-6653 (Electronic)1759-6653 (Linking)},
	author = {Sackton, T. B. and Hartl, D. L.}
}
