Citation:
Abstract:
Using parasite genotyping tools, we screened patients with mild uncomplicated malaria seeking treatment at a clinic in Thies, Senegal, from 2006 to 2011. We identified a growing frequency of infections caused by genetically identical parasite strains, coincident with increased deployment of malaria control interventions and decreased malaria deaths. Parasite genotypes in some cases persisted clonally across dry seasons. The increase in frequency of genetically identical parasite strains corresponded with decrease in the probability of multiple infections. Further, these observations support evidence of both clonal and epidemic population structures. These data provide the first evidence of a temporal correlation between the appearance of identical parasite types and increased malaria control efforts in Africa, which here included distribution of insecticide treated nets (ITNs), use of rapid diagnostic tests (RDTs) for malaria detection, and deployment of artemisinin combination therapy (ACT). Our results imply that genetic surveillance can be used to evaluate the effectiveness of disease control strategies and assist a rational global malaria eradication campaign.
Notes:
Daniels, RachelChang, Hsiao-HanSene, Papa DiogoyePark, Danny CNeafsey, Daniel ESchaffner, Stephen FHamilton, Elizabeth JLukens, Amanda KVan Tyne, DariaMboup, SouleymaneSabeti, Pardis CNdiaye, DaoudaWirth, Dyann FHartl, Daniel LVolkman, Sarah Keng1R01AI075080-01A1/AI/NIAID NIH HHS/1R56AI082589/AI/NIAID NIH HHS/5R01GM061351/GM/NIGMS NIH HHS/D43TW001503/TW/FIC NIH HHS/R01 AI099105/AI/NIAID NIH HHS/T32 AI007535/AI/NIAID NIH HHS/T32 AI007638/AI/NIAID NIH HHS/Research Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov't2013/04/18 06:00PLoS One. 2013 Apr 4;8(4):e60780. doi: 10.1371/journal.pone.0060780. Print 2013.