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Evidence for DNA loss as a determinant of genome size

Citation:

Petrov, DA, TA Sangster, JS Johnston, DL Hartl, and KL Shaw. 2000. “Evidence for DNA loss as a determinant of genome size.” Science 287: 1060-2.

Date Published:

Feb 11

Abstract:

Eukaryotic genome sizes range over five orders of magnitude. This variation cannot be explained by differences in organismic complexity (the C value paradox). To test the hypothesis that some variation in genome size can be attributed to differences in the patterns of insertion and deletion (indel) mutations among organisms, this study examines the indel spectrum in Laupala crickets, which have a genome size 11 times larger than that of Drosophila. Consistent with the hypothesis, DNA loss is more than 40 times slower in Laupala than in Drosophila.

Notes:

Petrov, D ASangster, T AJohnston, J SHartl, D LShaw, K LengResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.New York, N.Y.2000/02/11 09:00Science. 2000 Feb 11;287(5455):1060-2.

Last updated on 05/20/2015