Missense meanderings in sequence space: a biophysical view of protein evolution


Depristo, MA, DM Weinreich, and DL Hartl. 2005. “Missense meanderings in sequence space: a biophysical view of protein evolution.” Nat Rev Genet 6: 678-87.

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Proteins are finicky molecules; they are barely stable and are prone to aggregate, but they must function in a crowded environment that is full of degradative enzymes bent on their destruction. It is no surprise that many common diseases are due to missense mutations that affect protein stability and aggregation. Here we review the literature on biophysics as it relates to molecular evolution, focusing on how protein stability and aggregation affect organismal fitness. We then advance a biophysical model of protein evolution that helps us to understand phenomena that range from the dynamics of molecular adaptation to the clock-like rate of protein evolution.


DePristo, Mark AWeinreich, Daniel MHartl, Daniel LengResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.ReviewEngland2005/08/03 09:00Nat Rev Genet. 2005 Sep;6(9):678-87.

Last updated on 05/12/2015